Side Effects Of Temaril P?
My vet gave me this pills to get my dog for flea allergy. He told me they were safe and i looked on the net and these are the side effects. Can someone tell me what they mean? I gave him the meds yesterday and started him on them today.
All precautions applicable to cortisone and phenothiazine derivatives apply to TEMARIL-P. Possible side effects include sodium retention, potassium loss, suppressed adrenal cortical function, vomiting, diarrhea, sedation, blood dyscrasias, delayed wound healing and osteoporosis.
Cushing?s syndrome in dogs has been reported with prolonged or repeated steroid therapy.
Possible immunosuppressive effect may occur in patients receiving corticosteroids.
Tagged with: Effects • Side • Temaril
Filed under: Flea Allergies In Dogs
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Since Temaril-P is a combination of a steroid and an antihistamine, it should be used only as directed. From what I remember, there is only about 2.5mg of cortisone in each dose, which is very low. Steroids can cause problems such as Cushing’s Disease if used for long periods of time. They do suppress the immune system, and they may make your dog want to drink more and urinate more frequently.
Your vet probably gave you a dose to start out with for a few days, then gradually back your him down off the medication. They do this because the cortisone suppresses your dog’s adrenal glands. Basically his adrenal glands go back to working normally gradually. If you stop the medication abruptly, it can cause major problems.
My vets have prescribed this medication for my dog with allergies in the past, when the antihistamines were not helping alone. I have used it sporadically, and my dog has done well. I have seen other dogs respond to it well, too. As long as you follow your vet’s instructions and your dog is not on it for long periods of time, he should get some relief from the itching and be just fine.
I’m not a vet, but I hope this helps.
My dog has skin allergies, and she takes Temeril P. It’s a steroid, and can have the same effects as all steroids including liver disease, but truthfully, I haven’t noticed any difference. She’s been on it about a month, and her skin is still really bad.
Temaril-P Tablets®
Active Ingredients:
Composition: Each tablet contains trimeprazine tartrate (USP) 10-[3-(Dimethylamino)-2-methylpropyl] phenothiazine tartrate (2:1) equivalent to trimeprazine, 5 mg, and prednisolone, 2 mg.
Indications:
Recommendations for use:
1. Antipruritic: TEMARIL-P® is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular, and nonspecific). It often relieves pruritus which does not respond to other therapy. With any pruritus treatment, the cause should be determined and corrected; otherwise, signs are likely to recur following discontinuance of therapy.
2. Antitussive: TEMARIL-P® has been found to be effective therapy and adjunctive therapy in various cough conditions of dogs. Therefore, in addition to its Antipruritic action, TEMARIL-P® is recommended for the treatment of “kennel cough” or tracheobronchitis, bronchitis including all allergic bronchitis and infections and coughs of nonspecific origin. (Coughs due to cardiac insufficiencies would not be expected to respond to TEMARIL-P® therapy.) As with any Antitussive treatment, the etiology of the cough should be determined and eliminated if possible. Otherwise, symptoms are likely to recur following discontinuance of therapy.
Pharmacology:
Action: The exclusive TEMARIL-P® formula combines the Antipruritic and Antitussive action of trimeprazine with the anti-inflammatory action of prednisolone. A therapeutic effect is attained by administering the tablets twice daily.
Note: TEMARIL-P® may be administered to animals suffering from acute or chronic bacterial infections provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents.
Dosage and Administration:
Recommended Dosage: The same dosage schedule may be followed for both Antipruritic and Antitussive therapy.
Weight of Dog Initial Dosage
up to 10 lb ½ tablet, twice daily
11-20 lb 1 tablet, twice daily
21-40 lb 2 tablets, twice daily
over 40 lbs 3 tablets, twice daily
After 4 days, reduce dosage to ½ of the initial dose or to an amount just sufficient to maintain remission of symptoms. Individual animal response will vary and dosage should be adjusted until proper response is obtained.
Precautions:
Store in a dry, cool place at temperatures not above 25°C (77°F).
Cautions:
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
All the cautions applicable to cortisone and to phenothiazine derivatives apply also to TEMARIL-P®.
Prolonged treatment with TEMARIL-P® must be withdrawn gradually. Use of corticosteroids, depending on dose, duration, and specific steroid, may result in inhibition of endogenous steroid production following drug withdrawal. In patients presently receiving or recently withdrawn from systemic steroid treatments, therapy with a rapidly acting corticosteroid should be considered in unusually stressful situations.
Warnings:
Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies, including deformed forelegs, phocomelia, and anasarca. If a vasoconstrictor is needed, norepinephrine should be used in lieu of epinephrine. Phenothiazine derivatives may reverse the usual elevating action of epinephrine causing further lowering of blood pressure.
Side Effects:
Possible side effects attributable to corticosteroids include sodium retention and potassium loss, negative nitrogen balance, suppressed adrenal cortical function, delayed wound healing, osteoporosis, elevated levels of SGPT and SAP, and vomiting and diarrhea (occasionally bloody). Cushing’s syndrome in dogs has been reported in association with prolonged or repeated steroid therapy. Possible increased susceptibility to bacterial invasion and/or the exacerbation of preexisting bacterial infection may occur in patients receiving corticosteroids. As noted above, however, this problem can be avoided by concomitant use of appropriate anti-infective agents. Possible side effects attributable to phenothiazine derivatives include sedation; protruding nictitating membrane; blood dyscrasias; intensification and prolongation of the action of analgesics, sedatives and general anesthetics; and potentiation of organophosphate toxicity and the activity of procaine hydrochloride.
It should be remembered that the premonitory signs of cortisone over-dosage, such as sodium retention and edema, may not occur with prednisolone. Therefore, the veterinarians must be alert to detect less obvious side effects, such as blood dyscrasias, polydipsia and polyuria.
The appearance and severity of side effects are dose related and are minimal at the recommended dosage level. If troublesome side effects are encountered, the dosage of TEMARIL-P® should be reduced and discontinued unless the severity of the condition being treated makes its relief paramount.
Product Information Provided by Pfizer Animal Health. ©Pfizer Animal Health
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